466 Bee venom Immunotherapy with Standardized Extract, Two Case Comunication and Clinical Progress

CAP value among the 3 groups. MANOVA multivariate analysis evaluated differences in overall CAPs and the effects of age, gender, Mueller grade and stings number. A P , 0.05 was considered statistically significant. Data were analysed by ‘SPSS’ 13.0 (SPSS Inc., Chicago, IL). We called NS patients to check if they were stung after VIT discontinuation. Results: We selected 84 NS, 72 SP3 and 76 SP5 patients. Specific YJ-IgE levels decreased during VIT, as CAPs are statistically different at time 0, 3 and 5 (P , 0.001). Considering CAP levels at the first control (CAP3), NS patients presented lower values than SP3 patients (P 1⁄4 0.002); no significant difference was found between NS and SP5 patients. At the last control (CAP5), CAP values of NS and SP5 patients were different (P 1⁄4 0.002) as well as between SP3 and SP5 patients (P 1⁄4 0.014). No significant difference was found between NS and SP3 patients. By MANOVA, IgE decrease was inversely correlated with Mueller grade (P 1⁄4 0.012) and age (P 1⁄4 0.002). We recalled all NS patients by phone, 7/84 (8.3%) patients related one well tolerated sting, as they did not develop any allergic reaction. Conclusions: In everyday practice if a patient never stung during VIT fulfils the temporal criterion, but specific IgE are not negative, a decrease of IgE levels ranging from 57 to 70% in respect to baseline might be a satisfactory parameter for stopping VIT. As a further confirmation of our conclusions, even if not statistically significant, all not stung patients were clinically protected after VIT discontinuation.